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Proton MR spectroscopy in Pelizaeus-Merzbacher disease.

Abstract
Proton MR spectroscopic findings in two patients with genetically defined Pelizaeus-Merzbacher disease revealed ratios of N-acetylaspartate/creatine and choline-containing compounds/creatine that were not significantly different from those found in a population of healthy subjects. These findings suggest that proton MR spectroscopy can aid in the diagnosis of Pelizaeus-Merzbacher disease.
AuthorsJ Takanashi, K Sugita, H Osaka, M Ishii, H Niimi
JournalAJNR. American journal of neuroradiology (AJNR Am J Neuroradiol) Vol. 18 Issue 3 Pg. 533-5 (Mar 1997) ISSN: 0195-6108 [Print] United States
PMID9090417 (Publication Type: Journal Article)
Chemical References
  • Aspartic Acid
  • N-acetylaspartate
  • Creatine
  • Choline
Topics
  • Adolescent
  • Aspartic Acid (analogs & derivatives, metabolism)
  • Child
  • Child, Preschool
  • Choline (metabolism)
  • Creatine (metabolism)
  • Diffuse Cerebral Sclerosis of Schilder (diagnosis, genetics, physiopathology)
  • Energy Metabolism (physiology)
  • Exons
  • Humans
  • Magnetic Resonance Spectroscopy
  • Male
  • Point Mutation (genetics)
  • Reference Values

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