Abstract | BACKGROUND: Topical glucocorticoids are the medical treatment of choice in a majority of patients suffering from nasal polyposis. Fluticasone propionate is a fluorinated steroid reported to be highly effective when used topically in the nose for seasonal and perennial allergic and nonallergic rhinitis. OBJECTIVES: To evaluate the efficacy and tolerability of intranasal fluticasone propionate in the treatment of long-standing polyposis. METHODS: Fifty-five patients with long-standing nasal polyposis were treated over a 26-week period with fluticasone propionate aqueous nasal spray 200 micrograms bid, beclomethasone dipropionate aqueous nasal spray 200 micrograms bid or placebo, administered intranasally in an aqueous spray in a double-blind, placebo-controlled parallel-group design at a single center. The primary efficacy endpoint was the physicians' assessment of symptoms and polyp score. Peak nasal inspiratory flow was performed twice daily and on every visit to evaluate the effect of the corticosteroids on nasal air flow. RESULTS: CONCLUSION:
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Authors | K Holmberg, S Juliusson, B Balder, D L Smith, D H Richards, G Karlsson |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 78
Issue 3
Pg. 270-6
(Mar 1997)
ISSN: 1081-1206 [Print] United States |
PMID | 9087151
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androstadienes
- Anti-Allergic Agents
- Anti-Inflammatory Agents
- Glucocorticoids
- Placebos
- Fluticasone
- Beclomethasone
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Topics |
- Administration, Intranasal
- Adult
- Aged
- Androstadienes
(administration & dosage)
- Anti-Allergic Agents
(administration & dosage)
- Anti-Inflammatory Agents
(administration & dosage)
- Beclomethasone
(administration & dosage)
- Female
- Fluticasone
- Glucocorticoids
- Humans
- Male
- Middle Aged
- Nasal Polyps
(drug therapy)
- Placebos
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