HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[A case of depression manifesting incessant pacing and wandering following discontinuation of antipsychotic drugs due to neuroleptic malignant syndrome: a possible involvement of withdrawal akathisia].

Abstract
A depressed 36-year-old woman manifesting a delusion of persecution was started on neuroleptics. In parallel with the increase of neuroleptics, she suffered from akathisia, such as wandering, and thereafter developed neuroleptic malignant syndrome. Thus, neuroleptics were discontinued. As a result, she manifested severer wandering, impairment of conversation, and unacceptable behavior (e.g. touching her stool) though neuroleptic malignant syndrome subsided. These symptoms improved following the administration of levomepromazine and amitriptyline. It seems difficult to regard these symptoms as just a prolongation of akathisia, since the level and frequency of akathisia increased. It also seems unlikely to regard these symptoms as those of agitated depression, since there were no complaints of irritability. On the other hand, it seems probable that "withdrawal akathisia" occurred following the discontinuation of neuroleptics and the reinstituted levomepromazine improved the withdrawal phenomena consisting of severer wandering, impairment of conversation, and unacceptable behavior.
AuthorsH Watanabe, T Terao
JournalJournal of UOEH (J UOEH) Vol. 19 Issue 1 Pg. 29-38 (Mar 01 1997) ISSN: 0387-821X [Print] Japan
PMID9084097 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Amitriptyline
  • Methotrimeprazine
Topics
  • Adult
  • Akathisia, Drug-Induced (complications)
  • Amitriptyline (therapeutic use)
  • Depression (complications)
  • Female
  • Humans
  • Methotrimeprazine (therapeutic use)
  • Neuroleptic Malignant Syndrome (therapy)
  • Psychomotor Agitation (drug therapy, etiology)
  • Substance Withdrawal Syndrome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: