Standard therapy versus autologous transplantation in multiple myeloma.

Abstract

The IFM 90 trial was designed to compare conventional chemotherapy (CC) and high-dose therapy (HDT). This trial demonstrated a significant superiority of HDT over CC regarding response rate, event-free-survival, and overall survival. Further improvements of HDT can be expected both in terms of feasibility (with the combined use of hematopoietic growth factors and peripheral blood stem cells) and in terms of response rate (using tandem transplants). A substantial improvement in long-term survival, however, will require the development of effective maintenance therapy to control the minimal residual disease present after transplant.

• Authors: M Attal, J L Harousseau
• Journal: Hematology/oncology clinics of North America (Hematol Oncol Clin North Am) Vol. 11 Issue 1 Pg. 133-46 (Feb 1997) ISSN: 0889-8588 [Print] United States
• PMID: 9081208 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Interferon-alpha
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Melphalan
• Carmustine
• Prednisone

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Bone Marrow Transplantation
• Carmustine (therapeutic use)
• Cyclophosphamide (therapeutic use)
• Doxorubicin (therapeutic use)
• Female
• Humans
• Interferon-alpha (therapeutic use)
• Male
• Melphalan (therapeutic use)
• Middle Aged
• Multiple Myeloma (therapy)
• Prednisone (therapeutic use)
• Prognosis
• Prospective Studies
• Vincristine (therapeutic use)