Antineoplastic and cytogenetic effects of complexes of Pd (II) with 4N-substituted derivatives of 2-acetyl-pyridine-thiosemicarbazone.

Abstract

The effect of novel Pd(II) complexes with derivatives of 2-acetyl-pyridinethisemicarbazone, N4-ethyl (HAc4Et) and 3-hexamethyleneiminylthiosemicarbazone (HAchexim), on Sister Chromatid Exchange (SCE) rates and human lymphocyte proliferation kinetics was studied. Also, the effect of Pd(II) complexes on DNA synthesis of P388 and L1210 cell cultures and against Leukemia P388 was investigated. Among these compounds, the compound Bis(3-hexamethyleneiminyl-2-acetylpyridine-thisemicarbazonato++ +) palladium (II) was found to be distinctly effective against Leukemia P388, in inhibiting incorporation of 3H-thymidine into DNA and in inducing SCEs and cell division delays.

• Authors: A Papageorgiou, Z Iakovidou, D Mourelatos, E Mioglou, L Boutis, A Kotsis, D Kovala-Demertzi, A Domopoulou, D X West, M A Dermetzis
• Journal: Anticancer research (Anticancer Res) 1997 Jan-Feb Vol. 17 Issue 1A Pg. 247-51 ISSN: 0250-7005 [Print] Greece
• PMID: 9066660 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Organoplatinum Compounds
• Thiosemicarbazones
• DNA

Topics

• Animals
• Antineoplastic Agents (pharmacology, toxicity)
• DNA (biosynthesis)
• Female
• Humans
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Inbred DBA
• Organoplatinum Compounds (pharmacology, toxicity)
• Sister Chromatid Exchange (drug effects)
• Structure-Activity Relationship
• Thiosemicarbazones (pharmacology)