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Reversal of protein-losing enteropathy with heparin therapy in three patients with univentricular hearts and Fontan palliation.

Abstract
We studied three pediatric patients with protein-losing enteropathy in conjunction with univentricular hearts and right atrial to pulmonary artery anastomosis (Fontan operation) before and during heparin therapy. Each patient showed dramatic improvements in symptoms, marked elevations in serum albumin levels, and quantitative reversal of enteric protein loss within a few weeks of beginning therapy. These findings suggest that heparin may be an important treatment for this poorly understood condition.
AuthorsJ P Donnelly, A Rosenthal, V P Castle, R D Holmes
JournalThe Journal of pediatrics (J Pediatr) Vol. 130 Issue 3 Pg. 474-8 (Mar 1997) ISSN: 0022-3476 [Print] United States
PMID9063428 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Serum Albumin
  • Heparin
Topics
  • Adolescent
  • Adult
  • Child
  • Double Outlet Right Ventricle (surgery)
  • Fontan Procedure
  • Heart Defects, Congenital (surgery)
  • Heparin (therapeutic use)
  • Humans
  • Male
  • Postoperative Complications (drug therapy)
  • Protein-Losing Enteropathies (drug therapy, etiology)
  • Serum Albumin (analysis)
  • Time Factors

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