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Single-dose benzathine penicillin in infants at risk of congenital syphilis--results of a randomised study.

AbstractOBJECTIVE:
To determine the efficacy of single-dose benzathine penicillin G in infants at high risk of congenital syphilis.
DESIGN:
Randomised study comparing benzathine penicillin with no therapy.
SETTING:
Peninsula Maternal and Neonatal Service, Cape Town.
SUBJECTS:
Asymptomatic infants born to mothers with untreated syphilis whose VDRL titre was 32 or more.
OUTCOME MEASURES:
The number of cases of congenital syphilis was determined by results of IgM Western blots and follow-up VDRL titres.
RESULTS AND CONCLUSIONS:
Of 8 patients followed up in the non-treatment group, 4 had congenital syphilis while 0/11 had the disease (P = 0.035) in the group receiving benzathine penicillin. Although the exact failure rate is unknown, benzathine penicillin is effective in preventing symptomatic congenital syphilis when administered to high-risk newborns.
AuthorsM Radcliffe, M Meyer, D Roditi, A Malan
JournalSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 87 Issue 1 Pg. 62-5 (Jan 1997) ISSN: 0256-9574 [Print] South Africa
PMID9063317 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Immunoglobulin M
  • Penicillins
  • Penicillin G Benzathine
Topics
  • Blotting, Western
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoglobulin M (blood)
  • Infant, Newborn
  • Penicillin G Benzathine (administration & dosage, therapeutic use)
  • Penicillins (administration & dosage, therapeutic use)
  • Pregnancy
  • Pregnancy Complications, Infectious
  • South Africa
  • Syphilis
  • Syphilis Serodiagnosis
  • Syphilis, Congenital (diagnosis, prevention & control)
  • Treatment Outcome

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