Abstract | BACKGROUND: METHODS: Multilammelar liposomes containing bupivacaine were assessed using a rat paw wound model. Twenty-four hours after surgical incision, paw wounds determined to be hyperalgesic to graded force testing with von Frey hairs were infiltrated with 0.3 ml of 2% liposomal bupivacaine, 0.5% plain bupivacaine, saline, or "empty' ( normal saline) liposomes (n = 6/group). The duration of analgesia was measured. The 0.5% plain concentration was chosen because, in preliminary experiments, larger doses were often fatal. Analgesia duration was compared using Mann-Whitney U test at P < 0.05. In other rats, plasma bupivacaine levels after wound infiltration with either 2% liposomal formulation or 0.5% plain formulation were assessed (n = 8/group). RESULTS: CONCLUSIONS: The 8-fold increase in duration of wound analgesia and the lower plasma levels seen with the liposomal formulation are explained by gradual drug release from the liposomal depot. These results may have important implications for achieving safe and effective analgesia with wound infiltration techniques in humans.
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Authors | G J Grant, J Lax, L Susser, M Zakowski, T E Weissman, H Turndorf |
Journal | Acta anaesthesiologica Scandinavica
(Acta Anaesthesiol Scand)
Vol. 41
Issue 2
Pg. 204-7
(Feb 1997)
ISSN: 0001-5172 [Print] England |
PMID | 9062600
(Publication Type: Journal Article)
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Chemical References |
- Anesthetics, Local
- Drug Carriers
- Liposomes
- Bupivacaine
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Topics |
- Analgesia
- Anesthetics, Local
(administration & dosage, blood)
- Animals
- Bupivacaine
(administration & dosage, blood)
- Drug Carriers
- Liposomes
- Male
- Pain, Postoperative
(prevention & control)
- Rats
- Rats, Sprague-Dawley
- Time Factors
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