Comparison of the influence of cyclosporine and topical betamethasone-17,21-dipropionate treatment on quality of life in chronic hand eczema.

In a randomized, controlled parallel group study we have shown that cyclosporine at 3 mg/kg/day is as effective as topical betamethasone-17,21-dipropionate in the treatment of chronic hand eczema. In this study we compared the influence of these therapies on the quality of life. Forty-one patients were treated with either treatment for 6 weeks, after which patients with failure were switched to the other treatment for another 6 weeks. Quality of life was assessed with the Eczema Disability Index (EDI) at baseline and at the end of both treatment periods. The total EDI score decreased significantly and to the same degree in both groups, i.e. from the mean value of 30.5 to 20.9 in the cyclosporine group and from 27.2 to 18.9 in the betamethasone-17,21-dipropionate group. Irrespective of the dimension of the EDI (daily activity, school/work, personal relationship, leisure, treatment), the difference between the treatment groups at the end of the first treatment period was not significant. In the second part of the study a slight further decrease in total score was observed, but without any difference between the groups. There was a significant correlation between changes in the total EDI score and changes in all the clinical assessments, i.e. disease activity, extent of the disease, itch, sleep disturbances and use of emollients. Though the significant correlation between the total EDI and clinical assessments makes quality of life assessments in hand eczema questionable, the missing correlation between some clinical assessments and dimensions of the EDI suggests that EDI views aspects of the disease not covered by clinical measures.
AuthorsH Granlund, P Erkko, S Reitamo
JournalActa dermato-venereologica (Acta Derm Venereol) Vol. 77 Issue 1 Pg. 54-8 (Jan 1997) ISSN: 0001-5555 [Print] NORWAY
PMID9059680 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Glucocorticoids
  • betamethasone-17,21-dipropionate
  • Cyclosporine
  • Betamethasone
  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Anti-Inflammatory Agents (therapeutic use)
  • Betamethasone (analogs & derivatives, therapeutic use)
  • Chronic Disease
  • Cyclosporine (therapeutic use)
  • Eczema (drug therapy)
  • Female
  • Glucocorticoids
  • Hand Dermatoses (drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Quality of Life

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