Renal failure associated with hepatitis C virus infection. Improvement in renal function after treatment with interferon-alpha.

Abstract

Hepatitis C virus infection can result in mixed cryoglobulinemia and associated clinical syndromes including membranoproliferative glomerulonephritis. Reports regarding the efficacy of interferon-alpha (IFN-alpha) in the treatment of patients with membranoproliferative glomerulonephritis and chronic hepatitis C infection have been inconclusive regarding improvement of renal function. We describe two patients with chronic hepatitis secondary to hepatitis C virus complicated by mixed cryoglobulinemia and membranoproliferative glomerulonephritis who developed severe renal failure which resolved after treatment with standard doses of IFN-alpha 2b.

• Authors: P L Moses, E L Krawitt, W Aziz, H L Corwin
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 42 Issue 2 Pg. 443-6 (Feb 1997) ISSN: 0163-2116 [Print] United States
• PMID: 9052533 (Publication Type: Case Reports, Journal Article)

Chemical References

• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins

Topics

• Adult
• Chronic Disease
• Cryoglobulinemia (complications)
• Female
• Glomerulonephritis, Membranoproliferative (complications, pathology, physiopathology)
• Hepatitis C (complications, pathology, therapy)
• Humans
• Interferon alpha-2
• Interferon-alpha (therapeutic use)
• Kidney (pathology, physiopathology)
• Liver (pathology)
• Male
• Recombinant Proteins
• Renal Insufficiency (etiology, physiopathology)