Clinical analysis was performed on non-steroidal
ointment therapy for 70 patients with refractory adult-type
atopic dermatitis by the clinical data and patient's own evaluation of the
therapy obtained through enquiries after discharge from the hospital. Forty cases (57%) were between 20 and 30 years old and the male and female ratio was 39/31. The clinical evaluations were subdivided into five groups; conditions worsened (n = 9), no-change (n = 9), slightly improved (n = 14), much improved (n = 29) and cured (n = 9). Although statistically not significant, the age of onset of
atopic dermatitis and the start of use of
steroid ointment was much higher while the duration of the
atopic dermatitis was much shorter in the remission patients. The duration of
steroid ointment therapy for the facial skin was significantly shorter in the remission group when compared to groups with worsened symptoms and no-change in symptoms. Family history and complications of atopic diseases, laboratory data including
IgE titer, eosinophils and RAST score were not statistically significant in any group except for a higher prevalence of
IgE antibodies against inhalant and food
allergens in the group with worsened symptoms. Most patients still used
steroid ointment on the trunk lesions while they ceased using from the topical
steroid on the facial lesions after discharge. Most frequent precipitating factors pointed out by the patients were emotional stress, irritation by sweat or UV light and longstanding use of
steroid ointment. Complications of cataracta and retinopathy were found in 12 cases. These results suggest that remission of adult-type refractory
atopic dermatitis can be achieved by the combination of careful daily
skin care, use of non-steroidal topical
ointment and minimizing the precipitating factors.