Abstract | AIMS: A multicentre, double-blind, placebo-controlled trial was conducted in 542 patients, randomized 7-10 days after myocardial infarction, to study the effect of nisoldipine coat-core ( nisoldipine-CC) on exercise after 6 months. Secondary endpoints included exercise-induced ischaemia, left ventricular function measured by Doppler echocardiography, adverse cardiac events and clinical outcome. METHODS AND RESULTS: Patients had reduced left ventricular ejection fraction between 25 and 50%, but no heart failure. Exercise time was not different in the two groups. Nisoldipine-CC prolonged time to 1 mm ST deviation (P = 0.03). There was an effect of nisoldipine-CC of +3.6 cm.s-1 on early peak velocity (P = 0.01) and of -6.2 ms on isovolumic relaxation time (P = 0.005), but no effects on left ventricular volumes or ejection fraction. There was a trend towards reduced mortality (one death in the nisoldipine-CC group vs seven in the placebo group. P < 0.07) and the combined end-point of mortality and cardiac events (P = 0.09). Peripheral oedema occurred in 49 patients assigned to nisoldipine-CC and two assigned to placebo (P < 0.001). There were no differences in non- cardiac events. CONCLUSIONS:
Nisoldipine-CC did not improve exercise time but increased time to 1 mm ST deviation, and improved diastolic left ventricular function. It is safe and well tolerated in post- infarction patients with impaired left ventricular function.
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Authors | |
Journal | European heart journal
(Eur Heart J)
Vol. 18
Issue 1
Pg. 31-40
(Jan 1997)
ISSN: 0195-668X [Print] England |
PMID | 9049513
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Calcium Channel Blockers
- Delayed-Action Preparations
- Nisoldipine
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Topics |
- Adult
- Aged
- Calcium Channel Blockers
(administration & dosage, adverse effects)
- Delayed-Action Preparations
- Double-Blind Method
- Echocardiography, Doppler
(drug effects)
- Electrocardiography
(drug effects)
- Exercise Test
(drug effects)
- Female
- Heart Failure
(diagnostic imaging, drug therapy, mortality)
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(diagnostic imaging, drug therapy, mortality)
- Nisoldipine
(administration & dosage, adverse effects)
- Survival Rate
- Treatment Outcome
- Ventricular Function, Left
(drug effects)
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