Doppler flow and echocardiography in functional cardiac insufficiency: assessment of nisoldipine therapy. Results of the DEFIANT-II Study. The DEFIANT-II Research Group.

Abstract

AIMS:

A multicentre, double-blind, placebo-controlled trial was conducted in 542 patients, randomized 7-10 days after myocardial infarction, to study the effect of nisoldipine coat-core (nisoldipine-CC) on exercise after 6 months. Secondary endpoints included exercise-induced ischaemia, left ventricular function measured by Doppler echocardiography, adverse cardiac events and clinical outcome.

METHODS AND RESULTS:

Patients had reduced left ventricular ejection fraction between 25 and 50%, but no heart failure. Exercise time was not different in the two groups. Nisoldipine-CC prolonged time to 1 mm ST deviation (P = 0.03). There was an effect of nisoldipine-CC of +3.6 cm.s-1 on early peak velocity (P = 0.01) and of -6.2 ms on isovolumic relaxation time (P = 0.005), but no effects on left ventricular volumes or ejection fraction. There was a trend towards reduced mortality (one death in the nisoldipine-CC group vs seven in the placebo group. P < 0.07) and the combined end-point of mortality and cardiac events (P = 0.09). Peripheral oedema occurred in 49 patients assigned to nisoldipine-CC and two assigned to placebo (P < 0.001). There were no differences in non-cardiac events.

CONCLUSIONS:

Nisoldipine-CC did not improve exercise time but increased time to 1 mm ST deviation, and improved diastolic left ventricular function. It is safe and well tolerated in post-infarction patients with impaired left ventricular function.

• Journal: European heart journal (Eur Heart J) Vol. 18 Issue 1 Pg. 31-40 (Jan 1997) ISSN: 0195-668X [Print] England
• PMID: 9049513 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Calcium Channel Blockers
• Delayed-Action Preparations
• Nisoldipine

Topics

• Adult
• Aged
• Calcium Channel Blockers (administration & dosage, adverse effects)
• Delayed-Action Preparations
• Double-Blind Method
• Echocardiography, Doppler (drug effects)
• Electrocardiography (drug effects)
• Exercise Test (drug effects)
• Female
• Heart Failure (diagnostic imaging, drug therapy, mortality)
• Humans
• Male
• Middle Aged
• Myocardial Infarction (diagnostic imaging, drug therapy, mortality)
• Nisoldipine (administration & dosage, adverse effects)
• Survival Rate
• Treatment Outcome
• Ventricular Function, Left (drug effects)