Abstract | BACKGROUND: OBJECTIVE: METHODS: Patients (n = 93) with tinea cruris and a positive potassium hydroxide examination and mycologic culture were enrolled. Of the 76 patients assessed for efficacy, 37 applied butenafine and 39 applied vehicle once daily for 2 weeks. Assessments were made at the end of the 2-week treatment period and 4 weeks after the end of treatment. RESULTS: Patients in the butenafine group had a higher mycologic cure rate by day 7 (66% vs 13%, p < 0.0001), with marked improvement 4 weeks after the end of treatment (81% vs 13%, p < 0.0001). They also had a higher rate of effective treatment at day 7 (29% vs 5%, p < 0.01) and at 4 weeks after treatment (73% vs 5%, p < 0.0001). Adverse events definitely related to butenafine treatment were limited to one case of burning sensation after application. CONCLUSION:
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Authors | J L Lesher Jr, D E Babel, D M Stewart, T M Jones, L Kaminester, M Goldman, J S Weintraub |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 36
Issue 2 Pt 1
Pg. S20-4
(Feb 1997)
ISSN: 0190-9622 [Print] United States |
PMID | 9039201
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Antifungal Agents
- Benzylamines
- Naphthalenes
- butenafine
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Topics |
- Administration, Topical
- Adult
- Aged
- Antifungal Agents
(blood, therapeutic use)
- Benzylamines
(blood, therapeutic use)
- Double-Blind Method
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Naphthalenes
(blood, therapeutic use)
- Patient Satisfaction
- Statistics, Nonparametric
- Tinea
(drug therapy)
- Treatment Outcome
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