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Butenafine 1% cream in the treatment of tinea cruris: a multicenter, vehicle-controlled, double-blind trial.

AbstractBACKGROUND:
Butenafine hydrochloride, a potent antifungal agent related to the allylamines, has been used in Japan for treating various cutaneous mycoses including tinea cruris.
OBJECTIVE:
We compared the safety and efficacy of butenafine hydrochloride and its vehicle when used once daily for 2 weeks to treat tinea cruris.
METHODS:
Patients (n = 93) with tinea cruris and a positive potassium hydroxide examination and mycologic culture were enrolled. Of the 76 patients assessed for efficacy, 37 applied butenafine and 39 applied vehicle once daily for 2 weeks. Assessments were made at the end of the 2-week treatment period and 4 weeks after the end of treatment.
RESULTS:
Patients in the butenafine group had a higher mycologic cure rate by day 7 (66% vs 13%, p < 0.0001), with marked improvement 4 weeks after the end of treatment (81% vs 13%, p < 0.0001). They also had a higher rate of effective treatment at day 7 (29% vs 5%, p < 0.01) and at 4 weeks after treatment (73% vs 5%, p < 0.0001). Adverse events definitely related to butenafine treatment were limited to one case of burning sensation after application.
CONCLUSION:
Butenafine applied once daily for 2 weeks is effective in treating tinea cruris. The proportion of patients cured increased between the end of treatment and 4 weeks after treatment.
AuthorsJ L Lesher Jr, D E Babel, D M Stewart, T M Jones, L Kaminester, M Goldman, J S Weintraub
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 36 Issue 2 Pt 1 Pg. S20-4 (Feb 1997) ISSN: 0190-9622 [Print] United States
PMID9039201 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Antifungal Agents
  • Benzylamines
  • Naphthalenes
  • butenafine
Topics
  • Administration, Topical
  • Adult
  • Aged
  • Antifungal Agents (blood, therapeutic use)
  • Benzylamines (blood, therapeutic use)
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Naphthalenes (blood, therapeutic use)
  • Patient Satisfaction
  • Statistics, Nonparametric
  • Tinea (drug therapy)
  • Treatment Outcome

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