[Value of cyclosporine in the treatment of the recurrence of nephrosis after renal transplantation].

From May 1992 to December 1994, 14 children with end stage renal failure secondary to steroid-resistant idiopathic nephrotic syndrome received a cadaver kidney graft. Immediate recurrence of the nephrotic syndrome occurred in four patients. In the four patients, a complete remission was observed shortly after the start of intravenous cyclosporin; two children received in addition methylprednisolone pulses for secondary rejection. Two children were still protein-free 9 and 15 months after transplantation. In the third patient, proteinuria relapsed after 9 months of complete remission and persisted in spite of the reintroduction of intravenous cyclosporin. The fourth graft was lost at 3.5 month from irreversible rejection. The creatinine clearance of the 3 functioning grafts was respectively: 73, 76 and 92 ml/mn/1.73 m2 16, 10 and 15 months after transplantation. Intravenous cyclosporin started shortly after the recurrence, maintaining blood levels between 200 and 300 ng/ml, may induce a remission in recurrent nephrotic syndrome after renal transplantation in childhood.
AuthorsB Ranchin, M F Gagnadoux, M Broyer, A Lehnert, A Juresco, N Chérif, D Jan, D Droz, M C Gubler, P Niaudet
JournalNéphrologie (Nephrologie) Vol. 17 Issue 8 Pg. 441-5 ( 1996) ISSN: 0250-4960 [Print] SWITZERLAND
Vernacular TitleIntérêt de la ciclosporine dans le traitement des récidives de néphrose après transplantation rénale.
PMID9036367 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Cyclosporine
  • Child, Preschool
  • Cyclosporine (therapeutic use)
  • Female
  • Humans
  • Kidney Failure, Chronic (surgery)
  • Kidney Transplantation
  • Male
  • Nephrotic Syndrome (drug therapy)
  • Recurrence

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: