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Autoantibodies detected to expressed K+ channels are implicated in neuromyotonia.

Abstract
Antibody-mediated autoimmunity underlies a diverse range of disorders, particularly in the nervous system where the extracellular domains of ion channels and receptors are especially vulnerable targets. We present here a novel means of detecting autoantibodies where the genes of the suspected target proteins are known, and use it to detect specific autoantibodies in acquired neuromyotonia (Isaacs' syndrome), a disorder characterized by hyperexcitable motor nerves and sometimes by central abnormalities. We expressed different human brain voltage-gated potassium channels in Xenopus oocytes by injecting the relevant alpha-subunit complementary RNA, and detected antibody binding by immunohistochemistry on frozen sections. Antibodies were detected to one or more human brain voltage-gated potassium channel in 12 of 12 neuromyotonia patients and none of 18 control subjects. The results establish neuromyotonia as a new antibody-mediated channelopathy and indicate the investigative potential of this molecular immunohistochemical assay.
AuthorsI K Hart, C Waters, A Vincent, C Newland, D Beeson, O Pongs, C Morris, J Newsom-Davis
JournalAnnals of neurology (Ann Neurol) Vol. 41 Issue 2 Pg. 238-46 (Feb 1997) ISSN: 0364-5134 [Print] United States
PMID9029073 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Autoantibodies
  • Potassium Channels
Topics
  • Autoantibodies (analysis)
  • Fasciculation (metabolism)
  • Humans
  • Potassium Channels (metabolism)

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