Abstract |
Persistence of down regulation of granuloma size was studied in mice chronically infected with Schistosoma mansoni and cured by chemotherapy. The animals were reinfected at 20-, 50-, 110-, and 140-day intervals after treatment, and sacrificed 60 days post- infection. Reinfected animals were able to modulate the granulomatous inflammatory response, thus preventing a new acute phase. These findings may contribute to the explanation for the decrease of morbidity from human schistosomiasis seen in endemic areas following mass treatment.
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Authors | P M Coelho, N H Toppa, J S Feldmann, R Gonçalves, R T Mello |
Journal | International journal for parasitology
(Int J Parasitol)
Vol. 26
Issue 12
Pg. 1393-5
(Dec 1996)
ISSN: 0020-7519 [Print] England |
PMID | 9024890
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Schistosomicides
- Oxamniquine
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Topics |
- Animals
- Granuloma
(etiology, parasitology)
- Inflammation
- Liver Diseases, Parasitic
(drug therapy, pathology)
- Mice
- Oxamniquine
(therapeutic use)
- Schistosomiasis mansoni
(complications, drug therapy, pathology)
- Schistosomicides
(therapeutic use)
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