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[Effectiveness of the radioactive strontium (89Sr) chloride agent, SMS.2P for pain palliation in patients with metastatic bone tumor in phase III multicenter clinical trial].

Abstract
The phase III clinical trial of strontium-89 chloride agent (SMS.2P) was performed in 90 patients with painful bone metastases secondary to prostate (53), breast (18) and other types of cancer (19). Some patients experienced a transient increase in pain or nausea and vomiting. However both symptoms subsided and serious side effects were not observed in any of the patients. As reported, we confirmed some abnormal changes in peripheral blood picture. A decrease in the number of white blood cells and platelets was considered to be partly a result of bone marrow suppression due to 89Sr irradiation. Pain was substantially improved after 89Sr therapy in 58% of the patients and there was some alleviation in 12%. The release from pain was accompanied by an improved quality of life for these patients including sleep patterns and morbidity. Some patients were able to resume their former life styles. Most of the improved patients experienced pain relief from days to one week following 89Sr therapy and in half cases, this remained effective for 2 or 3 months. There were even cases in which the pain relief continued over an observation period of time of clinical study.
AuthorsY Kimura, K Hamamoto, M Furudate, H Fukuda, F Shishido, K Endo, N Yui, K Kusakabe, K Suzuki, K Kawakami, K Ishii, K Koizumi, K Yokoyama, K Hisada, T Nakagawa, K Kasagi, J Konishi, Y Ichiya, K Masuda, M Nakajo, A Kubo, K Torizuka
JournalKaku igaku. The Japanese journal of nuclear medicine (Kaku Igaku) Vol. 33 Issue 12 Pg. 1347-58 (Dec 1996) ISSN: 0022-7854 [Print] Japan
PMID9023442 (Publication Type: Clinical Trial, Clinical Trial, Phase III, English Abstract, Journal Article, Multicenter Study)
Chemical References
  • strontium chloride
  • Strontium
Topics
  • Adult
  • Aged
  • Bone Neoplasms (radiotherapy, secondary)
  • Breast Neoplasms (pathology)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pain, Intractable (radiotherapy)
  • Palliative Care
  • Prostatic Neoplasms (pathology)
  • Strontium (therapeutic use)

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