[Detection of tuberculosis in children of new risk groups and efficacy of chemoprophylaxis].

Abstract

109 children at risk of tuberculosis frequently suffering from acute respiratory diseases (ARD) and 87 children with rare ARD have undergone a 3-month course of isoniazide chemoprophylaxis. In 95.0% of the examinees the above chemoprophylaxis lowered ARD morbidity to 1-2 times a year, reduced and stabilized tuberculin sensitivity, prevented tuberculosis. Isoniazide treatment of 87 children whose parents worked with cattle that might be infected prevented tuberculosis in them, diminished tuberculin sensitivity. It is thought valid that chemoprophylaxis should be given in sanatoria primarily to children exposed to two and more risk factors (epidemiological, age-sex, medicobiological, social).

• Authors: L A Mitinskaia, V F Elufimova, N V Iukhimenko, N D Demeshko, M P Altynova, G A Kufakova
• Journal: Problemy tuberkuleza (Probl Tuberk) Issue 6 Pg. 33-5 ( 1996) ISSN: 0032-9533 [Print] Russia (Federation)
• Vernacular Title: Vyiavlenie tuberkuleza u detei iz novykh grupp riska i effektivnost' khimioprofilaktiki.
• PMID: 9019765 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antitubercular Agents
• Isoniazid

Topics

• Adolescent
• Antitubercular Agents (therapeutic use)
• Chemoprevention (methods)
• Child
• Follow-Up Studies
• Humans
• Isoniazid (therapeutic use)
• Morbidity
• Retrospective Studies
• Risk Factors
• Treatment Outcome
• Tuberculin Test
• Tuberculosis, Pulmonary (diagnosis, epidemiology, prevention & control)