Interactions between alcohol and other drugs on open-field and temperature measurements in gerbils.

Abstract

Open-field activity and rectal temperature were measured in mongolian gerbils treated with alcholol (1 and 2 g/kg) only and when alcohol was combined with bemegride (20 and 40 mg/kg), DH-524 (20 mg/kg), or d-amphetamine (8 mg/kg). None of the purported antagonists normalized the alcholol-produced changes in the open-field test, nor did they reverse the alcohol-induced hypothermia. However, alcohol offered protection against bemegride-induced convulsion and death. When compared with pervious data (1) it is suggested that alcohol is differentiated from pentobarbital and diazepam on the basis of their interactional effects with bemegride.

• Authors: T U Järbe, G C Ohlin
• Journal: Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 227 Issue 1 Pg. 106-17 (May 1977) ISSN: 0003-9780 [Print] Belgium
• PMID: 901059 (Publication Type: Journal Article)

Chemical References

• Imidazoles
• Phenyl Ethers
• Ethanol
• Bemegride
• Dextroamphetamine

Topics

• Animals
• Behavior, Animal (drug effects)
• Bemegride (pharmacology)
• Body Temperature (drug effects)
• Dextroamphetamine (pharmacology)
• Drug Interactions
• Ethanol (pharmacology)
• Female
• Gerbillinae
• Imidazoles (pharmacology)
• Motor Activity (drug effects)
• Phenyl Ethers (pharmacology)