Abstract | OBJECTIVE: METHODS: Focal ischemia for 6 hours was produced by permanent occlusion of the middle cerebral artery in 15 anesthetized cats. Treatment with drug (n = 8) or vehicle (n = 7) was initiated at 5 minutes after ischemia and continued for 3 hours. Physiological variables were continuously monitored during experiments. We measured ischemic injury size, brain edema, and BBB permeability to Evans blue and determined regional cerebral blood flow by using laser doppler flowmetry. RESULTS: Both ischemic injury size and BBB permeability were smaller in the ifenprodil-treated group, compared with the saline-treated group (P < 0.05). Ifenprodil treatment also attenuated brain edema formation in the dense ischemic region, compared with saline treatment (1.035 +/- 0.002 versus 1.028 +/- 0.002, P < 0.05). There was no significant change in cerebral blood flow with ifenprodil treatment. CONCLUSION:
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Authors | M K Başkaya, A M Rao, D Donaldson, M R Prasad, R J Dempsey |
Journal | Neurosurgery
(Neurosurgery)
Vol. 40
Issue 2
Pg. 364-70; discussion 370-1
(Feb 1997)
ISSN: 0148-396X [Print] United States |
PMID | 9007871
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Excitatory Amino Acid Antagonists
- Piperidines
- Vasodilator Agents
- ifenprodil
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Topics |
- Animals
- Blood-Brain Barrier
(drug effects)
- Brain
(blood supply, pathology)
- Brain Edema
(pathology)
- Brain Ischemia
(pathology)
- Capillary Permeability
(drug effects)
- Cats
- Cerebral Infarction
(pathology)
- Excitatory Amino Acid Antagonists
(pharmacology)
- Female
- Male
- Piperidines
(pharmacology)
- Regional Blood Flow
(drug effects)
- Vasodilator Agents
(pharmacology)
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