Abstract | OBJECTIVE: METHODS: A double- hemorrhage canine model of vasospasm was used to study the efficacy of milrinone. Angiographic vasospasm and systemic hemodynamics were compared in a treatment group of animals that received a loading dose of milrinone (0.05 mg/kg, intravenously) and then slow-release (0.05 microgram/kg/min) milrinone pellets (n = 10) and a control group that received placebo pellets (n = 9), over an 8-day period after the initial subarachnoid hemorrhage. The hemorrhage was created by injection of 4 ml of autologous, nonheparinized, arterial blood into the cisterna magna on Days 1 and 3. Hemodynamic measurements, including cardiac output determinations, were made on Days 0, 1, 3, 6, and 8 with a pulmonary artery catheter, and angiographic vasospasm was assessed on Day 8 by comparison with baseline angiograms. RESULTS: Treatment with milrinone caused no significant changes in systemic hemodynamics. Angiographic vasospasm, however, was significantly reduced in the Day 8 angiograms for the treated group, compared with the control group (98.28 +/- 14.06 and 67.89 +/- 13.06% of original vessel cross-sectional area, respectively; P < 0.001). CONCLUSION:
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Authors | K Khajavi, I Ayzman, D Shearer, S C Jones, J H Levy, R A Prayson, C I Skibinski, J F Hahn, D Chyatte |
Journal | Neurosurgery
(Neurosurgery)
Vol. 40
Issue 2
Pg. 354-62; discussion 362-3
(Feb 1997)
ISSN: 0148-396X [Print] United States |
PMID | 9007870
(Publication Type: Journal Article)
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Chemical References |
- Phosphodiesterase Inhibitors
- Pyridones
- Vasodilator Agents
- Milrinone
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Topics |
- Animals
- Cerebral Angiography
(drug effects)
- Dogs
- Hemodynamics
(drug effects)
- Ischemic Attack, Transient
(pathology, prevention & control)
- Milrinone
- Phosphodiesterase Inhibitors
(pharmacology)
- Pyridones
(pharmacology)
- Subarachnoid Hemorrhage
(complications, pathology)
- Vasodilator Agents
(pharmacology)
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