Intravenous 4-methylpyrazole as an antidote for diethylene glycol and triethylene glycol poisoning: a case report.

Abstract	Diethylene glycol (DEG) intoxication resembles that of ethylene glycol, with progressive inebriation, anion gap metabolic acidosis, renal failure, coma and death. DEG is oxidized by alcohol dehydrogenase (ADH) to more toxic byproducts, thus blockade of ADH might be beneficial. Triethylene glycol (TEG), also metabolized by ADH, is less toxic. A young female suicidally ingested DEG and TEG, presenting in metabolic acidosis with coma. Given 4-methylpyrazole (4-MP), an ADH inhibitor, the acidosis resolved, the patient recovered and was discharged without sequelae. 4-MP, if supported by further studies, may be useful in DEG poisoning.
Authors	S W Borron, F J Baud, R Garnier
Journal	Veterinary and human toxicology (Vet Hum Toxicol) Vol. 39 Issue 1 Pg. 26-8 (Feb 1997) ISSN: 0145-6296 [Print] United States
PMID	9004463 (Publication Type: Case Reports, Journal Article)
Chemical References	Antidotes Ethylene Glycols Pyrazoles triethylene glycol Polyethylene Glycols diethylene glycol Fomepizole
Topics	Adolescent Antidotes (therapeutic use) Ethylene Glycols (poisoning) Female Fomepizole Humans Polyethylene Glycols (poisoning) Pyrazoles (therapeutic use)

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