Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice.

Abstract

C57BL/6J-Min/+ mice, which are heterozygous for a non-sense mutation in the Apc gene, provide a model for both familial adenomatous polyposis and sporadic colon cancers. In our study, gut tumors and small intestine lymphoid nodules were counted in Min mice fed fiber-enriched diets for 6 weeks. Neither starch-free wheat bran nor resistant starch modified the number of tumors. However, short-chain fructo-oligosaccharides dramatically reduced the incidence of colon tumors and concomitantly developed gut-associated lymphoid tissue. Our experiment shows that short-chain fructo-oligosaccharides counteract advanced stages of colon carcinogenesis, possibly via stimulation of antitumoral immunity by modulation of the colonic ecosystem.

• Authors: F Pierre, P Perrin, M Champ, F Bornet, K Meflah, J Menanteau
• Journal: Cancer research (Cancer Res) Vol. 57 Issue 2 Pg. 225-8 (Jan 15 1997) ISSN: 0008-5472 [Print] United States
• PMID: 9000559 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dietary Fiber
• Oligosaccharides

Topics

• Animals
• Bifidobacterium (drug effects, growth & development)
• Colon (immunology, microbiology)
• Colonic Neoplasms (immunology, prevention & control)
• Dietary Fiber (pharmacology)
• Female
• Fermentation
• Male
• Mice
• Mice, Inbred C57BL
• Oligosaccharides (chemistry, pharmacology)
• Peyer's Patches (drug effects, growth & development)
• Precancerous Conditions (immunology, prevention & control)