Abstract | PURPOSE: MATERIALS AND METHODS: A multicenter study was done comparing oral dosages (200 and 400 micrograms.) of desmopressin (4-week, randomized, double-blind phase followed by 12 weeks of open label treatment with 400 micrograms.) to 20 micrograms. nasal spray in 66 adults and adolescents 12 to 45 years old with primary nocturnal enuresis. RESULTS: No significant differences were found between the 2 doses of desmopressin tablets or between the tablets and 20 micrograms. nasal spray during the double-blind phase. However, patients who initially received 200 micrograms. desmopressin tablets experienced fewer wet nights after they completed 12 weeks of open label treatment when the dose was escalated to 400 micrograms. tablets. Those who received 400 micrograms. tablets initially maintained response during this phase. Desmopressin tablets were well tolerated at both dose levels: 96% of patients and 94% of physicians rated the tolerability as excellent. CONCLUSIONS:
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Authors | R A Janknegt, H M Zweers, K P Delaere, A G Kloet, S G Khoe, H J Arendsen |
Journal | The Journal of urology
(J Urol)
Vol. 157
Issue 2
Pg. 513-7
(Feb 1997)
ISSN: 0022-5347 [Print] United States |
PMID | 8996345
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Renal Agents
- Deamino Arginine Vasopressin
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Topics |
- Administration, Intranasal
- Administration, Oral
- Adolescent
- Adult
- Child
- Deamino Arginine Vasopressin
(administration & dosage, adverse effects)
- Double-Blind Method
- Enuresis
(drug therapy)
- Female
- Humans
- Male
- Middle Aged
- Renal Agents
(administration & dosage, adverse effects)
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