Abstract | BACKGROUND: METHODS: Sixty patients (53 men and seven women), mean age 52 years (range 36-60 years), were studied. After a 4-week placebo period, patients were randomly assigned to three groups. The first group (n = 20) received simvastatin (20 mg daily), the second group (n = 20) ciprofibrate (100 mg daily) and the third group (n = 20) the combination of both drugs for a 12-week period. Parameters measured were as follows: plasma fibrinogen, total cholesterol, triglycerides, low density lipoprotein ( LDL), very low density lipoprotein, intermediate density lipoprotein, and high density lipoprotein cholesterol, as well as LDL subfraction distribution and structure by density gradient ultracentrifugation. Apoproteins ( apo) B and AI were assessed by immunoturbidometry. RESULTS: CONCLUSION:
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Authors | A G Kontopoulos, V G Athyros, A A Papageorgiou, H A Hatzikonstandinou, M C Mayroudi, H Boudoulas |
Journal | Coronary artery disease
(Coron Artery Dis)
Vol. 7
Issue 11
Pg. 843-50
(Nov 1996)
ISSN: 0954-6928 [Print] England |
PMID | 8993943
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Fibric Acids
- Hypolipidemic Agents
- Lipids
- Lipoproteins, LDL
- Clofibric Acid
- Fibrinogen
- Lovastatin
- Simvastatin
- ciprofibrate
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Topics |
- Adult
- Analysis of Variance
- Clofibric Acid
(adverse effects, analogs & derivatives, therapeutic use)
- Coronary Disease
(blood, drug therapy, epidemiology)
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Fibric Acids
- Fibrinogen
(metabolism)
- Follow-Up Studies
- Humans
- Hyperlipidemia, Familial Combined
(blood, drug therapy, epidemiology)
- Hypolipidemic Agents
(adverse effects, therapeutic use)
- Lipids
(blood)
- Lipoproteins, LDL
(blood, chemistry)
- Lovastatin
(adverse effects, analogs & derivatives, therapeutic use)
- Male
- Middle Aged
- Morbidity
- Prospective Studies
- Safety
- Simvastatin
- Survival Rate
- Treatment Outcome
- Ultracentrifugation
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