Successful treatment of onychomycosis with fluconazole in two patients with hyperimmunoglobulin E syndrome.

We report two patients with hyperimmunoglobulin E syndrome who had fingernail onychomycosis and were successfully treated with fluconazole. Relapse of oral candidiasis, but not of onychomycosis, was observed within three months of stopping fluconazole. There were no adverse effects from this therapy. Based on our experience, we think that fluconazole may be useful in the treatment of onychomycosis in patients with hyper-IgE syndrome as well as in those with other primary immunodeficiency disorders.
AuthorsY Aihara, M Mori, S Yokota
JournalPediatric dermatology (Pediatr Dermatol) 1996 Nov-Dec Vol. 13 Issue 6 Pg. 493-5 ISSN: 0736-8046 [Print] UNITED STATES
PMID8987061 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antifungal Agents
  • Fluconazole
  • Adolescent
  • Antifungal Agents (therapeutic use)
  • Child
  • Female
  • Fluconazole (therapeutic use)
  • Hand Dermatoses (drug therapy, etiology)
  • Humans
  • Job Syndrome (complications)
  • Male
  • Onychomycosis (drug therapy, etiology)

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