Fungemia in patients with hematologic malignancies: therapeutic effects of concomitant administration of fluconazole and granulocyte-colony-stimulating factor.

Serum (beta 1-->3)-D-glucan was elevated in 34 of 126 patients (27%) with hematologic malignancy who were clinically suspected of having a deep-seated mycosis. Although 11 patients (8.8%) were thought to have fungemia, fungi were isolated from blood culture in only 4. These results suggest that measurement of serum beta-D-glucan is useful for early diagnosis. Therapy with fluconazole (FLCZ) was effective in 9 of 11 patients (81.8%) suspected of having fungemia. Fungemia responded in 5 of 7 patients who were given granulocyte-colony-stimulating factor (G-CSF) concomitantly with FLCZ. This result suggested that administration of G-CSF with FLCZ was useful therapy for fungemia, which may occur during granulocytopenia following chemotherapy with anticancer agents.
AuthorsN Niitsu, M Umeda
JournalChemotherapy (Chemotherapy) 1996 May-Jun Vol. 42 Issue 3 Pg. 215-19 ISSN: 0009-3157 [Print] SWITZERLAND
PMID8983890 (Publication Type: Journal Article)
Chemical References
  • Adjuvants, Immunologic
  • Antifungal Agents
  • Glucans
  • Recombinant Proteins
  • Granulocyte Colony-Stimulating Factor
  • lenograstim
  • Fluconazole
  • Adjuvants, Immunologic (therapeutic use)
  • Antifungal Agents (therapeutic use)
  • Drug Therapy, Combination
  • Fluconazole (therapeutic use)
  • Fungemia (blood, diagnosis, drug therapy)
  • Glucans (blood)
  • Granulocyte Colony-Stimulating Factor (therapeutic use)
  • Hematologic Diseases (complications)
  • Humans
  • Recombinant Proteins (therapeutic use)

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