Abstract |
n- Docosanol has been shown to have antiviral activity. To demonstrate the efficacy of n- docosanol 10% cream in the treatment of recurrent herpes labialis, a randomised, double-blind, parallel group, placebo-controlled study was undertaken in 63 patients. In a crossover extension, 22 of the patients used the alternative treatment for a further episode. A total of 98 episodes were evaluated. Application of n- docosanol 10% cream early in the prodromal or erythema stage of a recurrent episode of herpes labialis shortened mean healing time by approximately 3 days, as compared to late treatment with n- docosanol 10% cream and early or late treatment with the placebo. The crossover study revealed that late treatment with n- docosanol 10% cream significantly reduced mean healing time compared to placebo. Treatments were well tolerated.
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Authors | L Habbema, K De Boulle, G A Roders, D H Katz |
Journal | Acta dermato-venereologica
(Acta Derm Venereol)
Vol. 76
Issue 6
Pg. 479-81
(Nov 1996)
ISSN: 0001-5555 [Print] Sweden |
PMID | 8982417
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antiviral Agents
- Fatty Alcohols
- Ointments
- docosanol
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Topics |
- Adolescent
- Adult
- Antiviral Agents
(administration & dosage, adverse effects)
- Double-Blind Method
- Fatty Alcohols
(administration & dosage, adverse effects)
- Herpes Labialis
(drug therapy)
- Humans
- Middle Aged
- Ointments
- Recurrence
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