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n-Docosanol 10% cream in the treatment of recurrent herpes labialis: a randomised, double-blind, placebo-controlled study.

Abstract
n-Docosanol has been shown to have antiviral activity. To demonstrate the efficacy of n-docosanol 10% cream in the treatment of recurrent herpes labialis, a randomised, double-blind, parallel group, placebo-controlled study was undertaken in 63 patients. In a crossover extension, 22 of the patients used the alternative treatment for a further episode. A total of 98 episodes were evaluated. Application of n-docosanol 10% cream early in the prodromal or erythema stage of a recurrent episode of herpes labialis shortened mean healing time by approximately 3 days, as compared to late treatment with n-docosanol 10% cream and early or late treatment with the placebo. The crossover study revealed that late treatment with n-docosanol 10% cream significantly reduced mean healing time compared to placebo. Treatments were well tolerated.
AuthorsL Habbema, K De Boulle, G A Roders, D H Katz
JournalActa dermato-venereologica (Acta Derm Venereol) Vol. 76 Issue 6 Pg. 479-81 (Nov 1996) ISSN: 0001-5555 [Print] Sweden
PMID8982417 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Antiviral Agents
  • Fatty Alcohols
  • Ointments
  • docosanol
Topics
  • Adolescent
  • Adult
  • Antiviral Agents (administration & dosage, adverse effects)
  • Double-Blind Method
  • Fatty Alcohols (administration & dosage, adverse effects)
  • Herpes Labialis (drug therapy)
  • Humans
  • Middle Aged
  • Ointments
  • Recurrence

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