Increased mutagen-induced chromosome damage in patients with transformed laryngeal pre-cancerosis.

Abstract

Factors that contribute to malignant transformation of laryngeal pre-neoplastic lesions remain largely unknown. Potential etiological factors may be related to a genetically controlled sensitivity to environmental carcinogens. In this study, we investigated bleomycin-induced chromosome damage in 15 patients who experienced a malignant transformation of preneoplastic laryngeal lesions during follow-up, as compared with chromosome fragility in 30 historical controls with no progression of keratoses during a 10-year follow-up, in a match-paired analysis. Chromosomal analysis demonstrated higher sensitivity to clastogens in patients with malignant progression of laryngeal pre-neoplastic lesions than that of control patients with no evolution of their original laryngeal keratoses (p = 0.003). Furthermore, among the study patients, chromosome sensitivity was most apparent in non-tobacco users with malignant transformation of laryngeal disease. Our data suggest that subjects with pre-neoplastic laryngeal lesion showing increased susceptibility to carcinogens could be at higher risk for development of laryngeal carcinoma.

• Authors: O Gallo, R Santoro, S Lenzi, V Boddi, M L Giovannucci-Uzielli
• Journal: International journal of cancer (Int J Cancer) Vol. 68 Issue 6 Pg. 700-3 (Dec 11 1996) ISSN: 0020-7136 [Print] United States
• PMID: 8980169 (Publication Type: Journal Article)

Chemical References

• Mutagens
• Bleomycin

Topics

• Adult
• Aged
• Bleomycin (toxicity)
• Case-Control Studies
• Cell Transformation, Neoplastic (genetics, pathology)
• Chromosome Aberrations (genetics)
• Cytogenetics
• Female
• Humans
• Laryngeal Diseases (genetics, pathology)
• Laryngeal Neoplasms (etiology)
• Lymphocytes (drug effects)
• Male
• Middle Aged
• Mutagens (toxicity)
• Precancerous Conditions (genetics, pathology)
• Smoking