Interleukin 6: a possible marker of disease activity in adult onset Still's disease.

Abstract

OBJECTIVE:

Adult onset Still's disease (AOSD) is an inflammatory disorder with elevated serum acute phase proteins. Interleukin-6 is a major contributor to the acute phase response. We therefore examined the serum levels of CRP, SAA and interleukin-6 in active and inactive AOSD.

RESULTS:

Active patients had significantly elevated CRP, SAA, and interleukin-6 values. After steroid treatment a marked reduction was observed in all three parameters. There was a close kinetics on the fluctuations of CRP and SAA, but not on IL-6.

CONCLUSION:

Acute phase proteins and IL-6 are useful markers of disease activity in AOSD.

• Authors: M A Scheinberg, E Chapira, M L Fernandes, O Hubscher
• Journal: Clinical and experimental rheumatology (Clin Exp Rheumatol) 1996 Nov-Dec Vol. 14 Issue 6 Pg. 653-5 ISSN: 0392-856X [Print] Italy
• PMID: 8978961 (Publication Type: Journal Article)

Chemical References

• Apolipoproteins
• Biomarkers
• Interleukin-6
• Serum Amyloid A Protein
• C-Reactive Protein

Topics

• Adult
• Aged
• Aged, 80 and over
• Apolipoproteins (metabolism)
• Biomarkers (blood)
• C-Reactive Protein (metabolism)
• Enzyme-Linked Immunosorbent Assay
• Humans
• Interleukin-6 (blood)
• Middle Aged
• Serum Amyloid A Protein (metabolism)
• Still's Disease, Adult-Onset (blood)