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Brief clinical report: glutamine-enriched total parenteral nutrition in a patient with radiation-induced renal and intestinal fibrosis.

Abstract
This brief clinical report illustrates the case of a 50-y-old male patient with severe radiation-induced renal and intestinal fibrosis who received glutamine-enriched total parenteral nutrition (TPN). The patient had end-stage renal disease and, therefore, underwent a kidney transplant. In the postoperative course the patient developed signs of bowel obstruction and cachexia. He received two courses of glutamine-enriched TPN before he underwent surgery for small bowel stenosis. Postoperatively, the patient received a third course of glutamine-enriched TPN. During the patient's hospital course the following indexes were monitored: patient's weight, serum concentrations of protein, albumin, and trialglycerol. Intestinal permeability was assessed with the lactulose-mannitol sugar test (L-M test). We measured changes in the patient's weight and the L-M test. We hypothesize that glutamine-enriched TPN may have been beneficial in the hospital course of this critically ill patient and may have influenced the patient's intestinal function and permeability.
AuthorsC Wicke, T Gottwald, H D Becker
JournalNutrition (Burbank, Los Angeles County, Calif.) (Nutrition) 1996 Nov-Dec Vol. 12 Issue 11-12 Suppl Pg. S85-6 ISSN: 0899-9007 [Print] United States
PMID8974127 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Glutamine
Topics
  • Fibrosis
  • Glutamine (administration & dosage)
  • Humans
  • Intestines (pathology, radiation effects)
  • Kidney (pathology, radiation effects)
  • Kidney Failure, Chronic (surgery)
  • Kidney Transplantation
  • Male
  • Middle Aged
  • Parenteral Nutrition, Total
  • Radiation Injuries

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