Effect of Pasteurella multocida toxin on in vivo immune responses in piglets.

Abstract

Atrophic rhinitis is characterized by a lack of an immune response towards Pasteurella multocida toxin (Pm-T). The effects of intranasal administration of Pm-T on cellular and T-cell dependent antibody responses of piglets against various other antigens were studied in a 3 by 2 factorial arrangement of treatments: three levels of challenge with Pm-T (either once; on three consecutive days; or no Pm-T challenge), and with or without simultaneous immunization with a "cocktail' containing Keyhole limpet haemocyanin (KLH), ovalbumin (OA) and tetanus toxoid (TT). Challenge with Pm-T affected but did not abolish the in vivo humoral immune response against OA, KLH, or TT. Pigs treated once with Pm-T showed lower total antibody responses, caused by lower IgG responses to the antigens. We found no clear consistent effects of Pm-T on cellular immune responses to the various T-cell-dependent antigens in vitro. The lack of immune responsiveness to Pm-T in Pm-T challenged pigs is discussed. The absence of detectable immune responses does not depend on a general suppression of the cellular immune system.

• Authors: P M van Diemen, G de Vries Reilingh, H K Parmentier
• Journal: The veterinary quarterly (Vet Q) Vol. 18 Issue 4 Pg. 141-6 (Dec 1996) ISSN: 0165-2176 [Print] England
• PMID: 8972062 (Publication Type: Journal Article)

Chemical References

• Antibodies, Bacterial
• Bacterial Proteins
• Bacterial Toxins
• Immunoglobulin G
• Immunoglobulin M
• Pasteurella multocida toxin
• Tetanus Toxoid
• Ovalbumin
• Hemocyanins

Topics

• Administration, Intranasal
• Animals
• Antibodies, Bacterial (metabolism)
• Bacterial Proteins
• Bacterial Toxins (administration & dosage, pharmacology)
• Dose-Response Relationship, Drug
• Female
• Hemocyanins (immunology)
• Immunoglobulin G (blood, metabolism)
• Immunoglobulin M (blood, metabolism)
• Male
• Ovalbumin (immunology)
• Pasteurella multocida (immunology)
• Random Allocation
• Swine (immunology)
• T-Lymphocytes (immunology, metabolism)
• Tetanus Toxoid (immunology)