Abstract | BACKGROUND: The pathogenesis of chronic idiopathic urticaria is characterized by defective histamine release. Skin mast cells show an increased release of histamine while circulating basophils are less responsive to immunologic stimulus. OBJECTIVE: The purpose of the study was to examine and compare the production of the histamine-releasing factor in the skin and within the peripheral blood of patients with chronic idiopathic urticaria and normal control subjects, as a possible factor responsible for the difference observed in the releasability of both skin mast cells and basophils. METHODS: RESULTS: CONCLUSION:
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Authors | J Claveau, A Lavoie, C Brunet, P M Bédard, J Hébert |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 77
Issue 6
Pg. 475-9
(Dec 1996)
ISSN: 1081-1206 [Print] United States |
PMID | 8970437
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Lymphokines
- Tumor Protein, Translationally-Controlled 1
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Topics |
- Adolescent
- Adult
- Aged
- Biomarkers, Tumor
- Chronic Disease
- Female
- Histamine Release
(drug effects)
- Humans
- Lymphokines
(analysis, blood)
- Male
- Middle Aged
- Skin
(chemistry)
- Tumor Protein, Translationally-Controlled 1
- Urticaria
(blood, etiology, metabolism)
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