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Prevention of restenosis after coronary angioplasty with low-density lipoprotein apheresis.

Abstract
A prospective study was performed to determine whether low-density lipoprotein (LDL) apheresis, when performed only immediately before and after percutaneous transluminal coronary angioplasty (PTCA), is effective in preventing restenosis of coronary artery lesions following PTCA. Thirty-six patients with coronary heart disease (CHD) and hypercholesterolemia were divided into 2 groups. The 9 patients in the LDL group underwent LDL-apheresis 1 day before and 5 days after PTCA while the 27 patients of the control group underwent PTCA but did not undergo LDL-apheresis. Follow-up coronary angiography (CAG) was performed 4 months after PTCA. The rate of restenosis of coronary artery lesions was significantly lower in the LDL group (0%) than in the control group (30%). These findings suggest that LDL-apheresis, when performed before and after PTCA, is effective in preventing restenosis of coronary artery lesions in patients with CHD and hypercholesterolemia.
AuthorsH Adachi, A Niwa, T Shinoda
JournalArtificial organs (Artif Organs) Vol. 19 Issue 12 Pg. 1243-7 (Dec 1995) ISSN: 0160-564X [Print] United States
PMID8967882 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Cholesterol, LDL
  • Lipoproteins, LDL
  • Triglycerides
  • Cholesterol
Topics
  • Aged
  • Angioplasty, Balloon, Coronary (adverse effects)
  • Blood Component Removal
  • Cholesterol (blood)
  • Cholesterol, LDL (blood)
  • Combined Modality Therapy
  • Coronary Disease (prevention & control, surgery)
  • Female
  • Humans
  • Hypercholesterolemia (therapy)
  • Lipoproteins, LDL (blood)
  • Male
  • Middle Aged
  • Postoperative Complications
  • Treatment Outcome
  • Triglycerides (blood)

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