Abstract |
A prospective study was performed to determine whether low-density lipoprotein ( LDL) apheresis, when performed only immediately before and after percutaneous transluminal coronary angioplasty (PTCA), is effective in preventing restenosis of coronary artery lesions following PTCA. Thirty-six patients with coronary heart disease (CHD) and hypercholesterolemia were divided into 2 groups. The 9 patients in the LDL group underwent LDL- apheresis 1 day before and 5 days after PTCA while the 27 patients of the control group underwent PTCA but did not undergo LDL- apheresis. Follow-up coronary angiography (CAG) was performed 4 months after PTCA. The rate of restenosis of coronary artery lesions was significantly lower in the LDL group (0%) than in the control group (30%). These findings suggest that LDL- apheresis, when performed before and after PTCA, is effective in preventing restenosis of coronary artery lesions in patients with CHD and hypercholesterolemia.
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Authors | H Adachi, A Niwa, T Shinoda |
Journal | Artificial organs
(Artif Organs)
Vol. 19
Issue 12
Pg. 1243-7
(Dec 1995)
ISSN: 0160-564X [Print] United States |
PMID | 8967882
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Cholesterol, LDL
- Lipoproteins, LDL
- Triglycerides
- Cholesterol
|
Topics |
- Aged
- Angioplasty, Balloon, Coronary
(adverse effects)
- Blood Component Removal
- Cholesterol
(blood)
- Cholesterol, LDL
(blood)
- Combined Modality Therapy
- Coronary Disease
(prevention & control, surgery)
- Female
- Humans
- Hypercholesterolemia
(therapy)
- Lipoproteins, LDL
(blood)
- Male
- Middle Aged
- Postoperative Complications
- Treatment Outcome
- Triglycerides
(blood)
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