[Examination of percutaneous minocycline hydrochloride injection therapy for hepatic cyst by one puncture method].

Abstract

Minocycline hydrochloride (MINO) at a dose of 500 mg (in principle) was injected into each of 11 hepatic cysts/10 cases (mean maximum diameter: 12.6 cm) that exhibited symptoms or a tendency toward growth by percutaneous transhepatic one puncture method, and the relation between therapeutic efficacy and pH of cystic fluid was examined. The efficacy was evaluated by abdominal CT after 3 months, and when a shrink of 50% or more in the maximum diameter was observed, it was judged as marked response. Marked effect was observed in 9 lesions of 11 (82%). This MINO injection therapy by one puncture method is very safe, simple and useful. Reduction in intra-cystic pH was not always related to the therapeutic efficacy, so involvement of cytotoxicity of MINO was suggested in degenerating the cystic epithelial cells.

• Authors: Y Tanaka, M Ogino, H Tokuda, M Mizuno, M Yamauchi, Y Iijima, K Hattori, T Kato, Y Komatsubara, H Kato, K Hayashi
• Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 93 Issue 11 Pg. 828-36 (Nov 1996) ISSN: 0446-6586 [Print] Japan
• PMID: 8953923 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Minocycline

Topics

• Adult
• Aged
• Cysts (drug therapy)
• Female
• Humans
• Injections, Intralesional
• Liver Diseases (drug therapy)
• Male
• Middle Aged
• Minocycline (administration & dosage)
• Treatment Outcome