[A case of cerebral aspergillosis associated with induction chemotherapy for acute lymphoblastic leukemia].

Abstract

A case of cerebral aspergillosis during induction chemotherapy for acute lymphoblastic leukemia was described. A 5-year-old boy complained of headache and left homonymous hemianopsia during induction chemotherapy for acute lymphoblastic leukemia. CT scan and MR imaging survey demonstrated cerebral fungal lesion as well as multifocal lung lesions. A cerebral lesion appeared as a low density mass in right occipital lobe with marginal enhancement on CT scan, and iso- and high-signal intensity appeared with marginal gadolinium enhancement on T1- and T2-weighted MR imaging. Although fungus balls in the lung responded well to daily intravenous administration of amphotericin-B for 2 months, the cerebral lesion showed a rather expansive character as invading into neighbouring falx, opposite occipital lobe, meninges, and occipital bone. Extensive removal of the brain lesion from the parenchyma, falx, invaded dura, and skull was surgically performed. The lesion was confirmed as aspergillosis by Grocott's methenamine histological stain. Surgical intervention and concomitant use of amphotericin-B for a month resulted in complete remission of the aspergillosis. After 6 years, a cranioplasty was successfully completed for the occipital bone defect.

• Authors: K Okamoto, A Kuroiwa, Y Yokoyama, F Kamoda, H Kinumaki, N Shitara
• Journal: No to shinkei = Brain and nerve (No To Shinkei) Vol. 48 Issue 11 Pg. 1047-51 (Nov 1996) ISSN: 0006-8969 [Print] Japan
• PMID: 8951897 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antifungal Agents
• Vincristine
• Amphotericin B
• Cyclophosphamide
• Prednisolone
• Asparaginase

Topics

• Amphotericin B (therapeutic use)
• Antifungal Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Asparaginase (administration & dosage)
• Aspergillosis (diagnosis, etiology, surgery)
• Brain Abscess (diagnosis, etiology, surgery)
• Child, Preschool
• Cyclophosphamide (administration & dosage)
• Humans
• Magnetic Resonance Imaging
• Male
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (complications, drug therapy)
• Prednisolone (administration & dosage)
• Tomography, X-Ray Computed
• Vincristine (administration & dosage)