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[High dose inhaled steroid therapy--usefulness and limitation].

Abstract
Our data indicate that 1800 micrograms of per day is more effective than 1400 micrograms/day at the beginning of long-term management of severe asthma in adults whose symptoms are not controlled with the combination of 800 approximately 900 micrograms/day BDP and bronchodilators. Therapy with a higher dose (at least 1600 micrograms/day) of inhaled steroid is more useful and should be promptly began to treat severe asthma. Oral steroid therapy for long-term management should be introduced to mostly severe case after high dose inhaled BDP therapy reveals to be failure.
AuthorsK Kudo
JournalNihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 54 Issue 11 Pg. 2993-7 (Nov 1996) ISSN: 0047-1852 [Print] Japan
PMID8950943 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Anti-Inflammatory Agents
  • Beclomethasone
  • Hydrocortisone
Topics
  • Administration, Inhalation
  • Adult
  • Anti-Inflammatory Agents (administration & dosage, adverse effects)
  • Asthma (drug therapy, physiopathology)
  • Beclomethasone (administration & dosage, adverse effects)
  • Chronic Disease
  • Female
  • Humans
  • Hydrocortisone (blood)
  • Male
  • Middle Aged
  • Peak Expiratory Flow Rate

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