Over a 2-year period (1992 to 1994), 12 consecutive adult patients with paroxysmal
laryngospasm were prospectively studied. All had had other symptoms of
gastroesophageal reflux (GER); however, only 4 (33%) experienced symptoms of
heartburn. Each patient underwent fiberoptic laryngeal examination,
barium swallow/esophagography, and ambulatory, 24-hour, double-probe pH monitoring (pH-metry). Eleven (92%) of the 12 patients had evidence of GER on examination, and 10 (83%) had abnormal pH-metry, including 3 who demonstrated pharyngeal reflux while having normal total
acid exposure times in the esophageal probe. All the patients responded to antireflux treatment, using dietary and lifestyle modifications and
omeprazole, with complete cessation of the laryngospastic episodes. This study documents the role of GER in the etiology of paroxysmal
laryngospasm, it highlights the advantages of double-probe pH-metry in diagnosing this extraesophageal manifestation of GER, and it demonstrates that antireflux
therapy with
omeprazole is effective in controlling GER-induced
laryngospasm.