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Diphencyprone in the management of refractory palmoplantar and periungual warts: an open study.

AbstractBACKGROUND:
Induction of delayed-type hypersensitivity has recently been introduced for resistant viral warts. The method is not painful and less destructive than most other modalities.
OBJECTIVE:
We assessed the efficacy of topical diphencyprone (diphenylcyclopropenone) treatment for recalcitrant warts.
METHODS:
From September 1988 to June 1995, 134 patients with periungual and/or palmoplantar warts were entered into the study. Eight weekly applications were delivered.
RESULTS:
The scheduled treatment course and follow-up were completed by 111 patients. There were 49 complete and 18 partial remissions. The rate of positive responders (60%) compares with the results published by other authors.
CONCLUSION:
Diphencyprone is an effective treatment for resistant warts, especially in palmoplantar and periungual locations.
AuthorsF H Rampen, P M Steijlen
JournalDermatology (Basel, Switzerland) (Dermatology) Vol. 193 Issue 3 Pg. 236-8 ( 1996) ISSN: 1018-8665 [Print] Switzerland
PMID8944347 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Adjuvants, Immunologic
  • Cyclopropanes
  • Dermatologic Agents
  • diphenylcyclopropenone
Topics
  • Adjuvants, Immunologic (administration & dosage, therapeutic use)
  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Aged
  • Cyclopropanes (administration & dosage, therapeutic use)
  • Dermatologic Agents (administration & dosage, therapeutic use)
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Foot Dermatoses (drug therapy, immunology)
  • Hand Dermatoses (drug therapy, immunology)
  • Humans
  • Hypersensitivity, Delayed (chemically induced, immunology)
  • Male
  • Middle Aged
  • Nail Diseases (drug therapy, immunology)
  • Remission Induction
  • Warts (drug therapy, immunology)

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