Abstract | INTRODUCTION: METHODS: In all cases the clinical diagnosis was confirmed by amoebal culture. In some instances identification of the protozoa by direct microscopy of corneal tissue was possible. The medication was provided topically in drop form until the keratitis had resolved. In vitro sensitivity to chlorhexidine and propamidine was performed on all isolates and compared with sensitivity to a range of other drugs used for treatment of the infection. RESULTS: In vitro drug testing confirmed that trophozoites and cysts of all 12 Acanthamoeba isolates were fully sensitive to chlorhexidine and propamidine. Therapy was satisfactory for controlling and eradicating the acanthamoebal infection in all patients. Three patients developed discrete stromal infiltration at the site of infection that resolved 1 week after commencing therapy, with or without use of steroids. Two patients developed a late inflammatory effect in the stromal scar at 6 months, which resolved with steroids. No clinical evidence of chlorhexidine toxicity was found in any patients. CONCLUSIONS:
|
Authors | D Seal, J Hay, C Kirkness, A Morrell, A Booth, A Tullo, A Ridgway, M Armstrong |
Journal | Eye (London, England)
(Eye (Lond))
Vol. 10 ( Pt 4)
Pg. 413-21
( 1996)
ISSN: 0950-222X [Print] England |
PMID | 8944089
(Publication Type: Case Reports, Journal Article, Multicenter Study)
|
Chemical References |
- Anti-Infective Agents
- Antiprotozoal Agents
- Benzamidines
- propamidine isethionate
- Chlorhexidine
|
Topics |
- Acanthamoeba
(isolation & purification)
- Acanthamoeba Keratitis
(drug therapy, pathology)
- Administration, Topical
- Adolescent
- Adult
- Animals
- Anti-Infective Agents
(adverse effects, therapeutic use)
- Antiprotozoal Agents
(adverse effects, therapeutic use)
- Benzamidines
(adverse effects, therapeutic use)
- Chlorhexidine
(adverse effects, therapeutic use)
- Contact Lenses
- Female
- Humans
- Male
- Microbiological Techniques
- Middle Aged
|