Abstract | BACKGROUND/AIMS: In a prospective study with a mean follow-up period of 12.5 +/- 3.5 months, we investigated the extracellular matrix components laminin and hyaluronan in serum for their diagnostic value in portal hypertension and in clinically severe complications of progressive liver cirrhosis. METHODS: RESULTS: Neither laminin nor hyaluronan correlated with portal hypertension, but highly significantly increased (p < 0.001) concentrations of 3.25 +/- 0.2 U/ml ( laminin) and 493 +/- 248 ng/ml ( hyaluronan) were found in patients with complications of liver cirrhosis when compared to those without complications (Ln: 2.13 +/- 0.26 U/ml, HA: 206 +/- 184 ng/ml). At cut-off levels of 2.6 U/ml ( laminin) and 200 ng/ ml ( hyaluronan), the diagnostic sensitivity and specificity for severe complications of liver cirrhosis was 0.71 and 0.86 (Ln) and 0.90 and 0.67 (HA), respectively. The positive predictive values were of 0.8 ( laminin) and 0.6 ( hyaluronan). The relative risk of patients presenting elevated concentrations of laminin or hyaluronan at the start of the study for later development of severe complications was 2.7. CONCLUSIONS: Both parameters, especially serum laminin, can be used as prognostic markers in addition to the Child criteria in liver cirrhosis.
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Authors | T Körner, J Kropf, A M Gressner |
Journal | Journal of hepatology
(J Hepatol)
Vol. 25
Issue 5
Pg. 684-8
(Nov 1996)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 8938546
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Laminin
- Hyaluronic Acid
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Topics |
- Adult
- Aged
- Analysis of Variance
- Biomarkers
(blood)
- Chi-Square Distribution
- Disease Progression
- Esophageal and Gastric Varices
(complications)
- Female
- Follow-Up Studies
- Humans
- Hyaluronic Acid
(blood)
- Hypertension, Portal
(complications)
- Laminin
(blood)
- Liver Cirrhosis
(blood, complications, pathology)
- Male
- Middle Aged
- Prognosis
- Prospective Studies
- Risk Assessment
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