Augmentation of tumor immunity by 6-MPG, a water-soluble derivative of 6-mercaptopurine, in mice.

Abstract

Inhibitory effects on some immunological responses and MethA fibrosarcoma in the double grafted tumor system in mice were compared between 6-mercaptopurine (6-MP) and its novel water-soluble derivative, gamma-(9H-purine-6-yl)thiomethyl L-glutamate (6-MPG). The dose-dependent inhibitory effects by 6-MPG on the hemagglutinin response to SRBC, DTH reaction to MBSA, contact sensitivity to oxazolone, GVH response and growth of the primary tumor were 3-10 times weaker than those by 6-MP, probably reflecting the difference in their cytotoxicities antimetabolites. However, the two drugs were nearly equipotent in reproducing inhibition of the secondary tumor growth, which is a host-mediated immunological response to tumor antigen as shown by its dependency on the primary inoculation with 1 x 10(4) or more MethA cells and by the production of anti-tumor splenocytes in tumor-bearing animals (the Winn assay). Thus, 6-MPG may point to the direction of derivatization towards anti-tumor immunopotentiators with an improved therapeutic index.

• Authors: T Kashida, N Narasaki, K Tsujihara, K Naito, S Takeyama
• Journal: International journal of immunopharmacology (Int J Immunopharmacol) Vol. 18 Issue 5 Pg. 311-9 (May 1996) ISSN: 0192-0561 [Print] England
• PMID: 8933210 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Mercaptopurine

Topics

• Adjuvants, Immunologic (pharmacology)
• Adoptive Transfer
• Animals
• Cell Division (drug effects, immunology)
• Fibrosarcoma (drug therapy, immunology, secondary)
• Hemagglutination (drug effects)
• Male
• Mercaptopurine (analogs & derivatives, pharmacology)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Neoplasm Transplantation
• Sarcoma, Experimental (drug therapy, immunology, secondary)
• Solubility
• Spleen (transplantation)