[Efficacy of levocabastine in perennial rhinitis].

Abstract

We have evaluated the efficacy of topical levocabastine in 42 patients (20 males and 22 females; mean age 37.5 yrs.) affected by perennial allergic rhinoconjunctivitis due to Dermatophagoides pteronyssinus. Diagnosis was performed on the basis of clinical history, Skin Prick test and RAST. The study lasted for 90 days and nasal spray levocabastine was administered at the dose of 2 puff in each nostril twice a day. Patients had to record the severity of the symptoms considered (sneezing, nasal pruritus, nasal obstruction and rhinorrhea) on a diary card according to an arbitrary score from 0 to 3. At the end of the treatment patients experienced a significant improvement of their symptoms and no side effects were recorded. On the basis of our results levocabastine can be considered a useful drug in the treatment of allergic rhinitis due to Dermatophagoides pteronyssinus.

• Authors: M L Pacor, D Biasi, T Maleknia, A Carletto, C Lunardi
• Journal: La Clinica terapeutica (Clin Ter) Vol. 147 Issue 6 Pg. 295-8 (Jun 1996) ISSN: 0009-9074 [Print] Italy
• Vernacular Title: Efficacia della levocabastina nelle riniti perenni.
• PMID: 8925638 (Publication Type: Clinical Trial, Clinical Trial, Phase II, English Abstract, Journal Article)

Chemical References

• Aerosols
• Histamine H1 Antagonists
• Piperidines
• levocabastine

Topics

• Administration, Intranasal
• Adult
• Aerosols (administration & dosage)
• Analysis of Variance
• Conjunctivitis (drug therapy, immunology)
• Female
• Histamine H1 Antagonists (administration & dosage)
• Humans
• Male
• Piperidines (administration & dosage)
• Rhinitis, Allergic, Perennial (drug therapy, immunology)