Abstract | BACKGROUND: The aim of the study was to approve the hypolipidemic potency of the new drug from the group of fibrate derivates Lipanthyl 200 M(R) (micronized fenofibrate, cps a 200 mg, Laboratoires Fournier, France) in patients with familial hyperlipoproteinemias. The drug has been administered in constant dose of 200 mg daily with the evening meal for three months. Clinical examinations and monitoring of safety laboratory have been performed in addition to complete analysis of lipids, lipoproteins and apolipoproteins during the study. METHODS AND RESULTS: The group of 30 patients consisted from 14 heterozygotes of familial hypercholesterolemia and 16 patients affected by familial combined hyperlipidemia. Levels of total, HDL- and LDL-cholesterol, triglycerides, apolipoproteins A-I and B and Lp(a) have been measured and concentrations of fibrinogen in plasma as well. Concentration of total cholesterol 8.29 +/- 1.3 mmol/l on the beginning of the study decreased after one and three months of the treatment to 6.94 +/- 1.19 resp. 6.98 +/- 1.21 mmol/l, concentration of triglycerides has been reduced from 2.86 +/- 1.29 mmol/l to 1.70 +/- 0.86 and 1.74 +/- 0.99 mmol/l respectively HDL-cholesterol raised from 1.14 +/- 0.32 mmol/l to 1.27 +/- 0.36 and to 1.34 +/- 0.37 mmol/l in contrast to decrease of LDL-cholesterol 5.88 +/- 1.53 mmol/l on the beginning of the study to 4.87 +/- 1.49 and 4.79 +/- 1.60. Apo B in plasma fall after three month period of the treatment from 1.83 +/- 0.43 g/l to 1.46 +/- 0.47 g/l. On the other hand the concentration of apolipoprotein apo A-I1.20 +/- 0.35 g/l increased to 1.40 +/- 0.32 g/l. Fibrinogen in plasma was reduced from 3.63 +/- 0.69 g/l to 2.77 +/- 0.50 g/l. Also this decrease was statistically significant. CONCLUSIONS:
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Authors | R Ceska, J Sobra, J Kvasnicka, R Procházková, M Kvasilová, T Haas |
Journal | Casopis lekaru ceskych
(Cas Lek Cesk)
Vol. 135
Issue 13
Pg. 413-6
(Jul 26 1996)
ISSN: 0008-7335 [Print] Czech Republic |
Vernacular Title | Vliv mikronizovaného fenofibrátu na lipidové parametry a fibrinogen u heterozygotů familiární hypercholesterolémie a familiární kombinované hyperlipidémie. |
PMID | 8925538
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Hypolipidemic Agents
- Lipids
- Fibrinogen
- Fenofibrate
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Topics |
- Adult
- Aged
- Female
- Fenofibrate
(administration & dosage)
- Fibrinogen
(analysis)
- Heterozygote
- Humans
- Hyperlipidemia, Familial Combined
(blood, drug therapy, genetics)
- Hyperlipoproteinemia Type II
(blood, drug therapy, genetics)
- Hypolipidemic Agents
(administration & dosage)
- Lipids
(blood)
- Male
- Middle Aged
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