HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Mycotoxin T-2 and aflatoxin B1 as immunosuppressors in mice chronically infected with Toxoplasma gondii.

Abstract
The aim of this study was to determine whether repeated ingestion of mycotoxin T-2 (T2) or aflatoxin B1 (AFL) at low doses could contribute to the activation of toxoplasmosis in experimentally infected mice. Mice were divided into two groups: Control (C) and Infected (I). The cyst-forming Beverley strain of Toxoplasma gondii was used to produce the infection one month before treatment with mycotoxins. Mycotoxins were given intragastrically for a 50-day period. The average weight gain was reduced in the groups treated with mycotoxins. Mice developed specific IgG to T. gondii. Histopathological studies showed severe encephalitis in all groups infected. The number of unruptured and ruptured cysts was established and the severity of the lesions was evaluated, the groups treated with mycotoxins being the most severely affected. Immunohistochemical studies of the brain showed free antigen in tissues surrounding ruptured cysts. It is suggested that low and repeated doses of mycotoxins, necessary to produce a subclinical intoxication, precipitate Toxoplasma cyst rupture and consequently the activation of chronic toxoplasmosis.
AuthorsM C Venturini, M A Quiroga, M A Risso, C D Lorenzo, Y Omata, L Venturini, H Godoy
JournalJournal of comparative pathology (J Comp Pathol) Vol. 115 Issue 3 Pg. 229-37 (Oct 1996) ISSN: 0021-9975 [Print] England
PMID8923234 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Protozoan
  • Antigens, Protozoan
  • Aflatoxin B1
  • T-2 Toxin
Topics
  • Aflatoxin B1 (pharmacology)
  • Animals
  • Antibodies, Protozoan (analysis)
  • Antigens, Protozoan (analysis)
  • Body Weight
  • Brain (pathology, ultrastructure)
  • Chronic Disease
  • Encephalitis (etiology, pathology)
  • Female
  • Immunohistochemistry
  • Immunosuppression Therapy
  • Liver (pathology)
  • Meningitis (etiology, pathology)
  • Mice
  • Microscopy, Electron
  • Organ Size
  • T-2 Toxin (pharmacology)
  • Toxoplasmosis, Animal (etiology, immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: