Abstract | OBJECTIVES: BACKGROUND: METHODS: RESULTS: Two weeks postoperatively, CHF accompanied by pulmonary hypertension developed in the rats (CHF rats). Expression of preproendothelin-1 mRNA in the lung was markedly higher in the CHF rats than in the sham-operated rats, whereas that in the kidney did not differ between the two groups. Endothelin-1 staining on the pulmonary vascular endothelial cells was more intense in the CHF rats. BQ-123 treatment over a 2-week period in the CHF rats greatly reduced right ventricular systolic pressure and central venous pressure, but it did not affect blood pressure or left ventricular contractility (peak positive first derivative of left ventricular pressure) in these rats. CONCLUSIONS:
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Authors | S Sakai, T Miyauchi, T Sakurai, I Yamaguchi, M Kobayashi, K Goto, Y Sugishita |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 28
Issue 6
Pg. 1580-8
(Nov 15 1996)
ISSN: 0735-1097 [Print] United States |
PMID | 8917275
(Publication Type: Journal Article)
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Chemical References |
- Endothelin Receptor Antagonists
- Endothelin-1
- Endothelins
- Peptides, Cyclic
- Protein Precursors
- RNA, Messenger
- proendothelin 1
- cyclo(Trp-Asp-Pro-Val-Leu)
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Topics |
- Animals
- Endothelin Receptor Antagonists
- Endothelin-1
(antagonists & inhibitors, metabolism, physiology)
- Endothelins
(genetics)
- Heart Failure
(complications, physiopathology)
- Hemodynamics
(drug effects)
- Hypertension, Pulmonary
(drug therapy, etiology, metabolism)
- Immunohistochemistry
- Kidney
(metabolism)
- Lung
(metabolism)
- Peptides, Cyclic
(therapeutic use)
- Protein Precursors
(genetics)
- RNA, Messenger
(genetics)
- Rats
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