Abstract | BACKGROUND: METHODS: Study participants included 89 women classified as American Society of Anesthesiologists physical status 1 or 2 who were scheduled for major breast surgery. Patients were randomly assigned to one of four groups. Group O received 4 mg ondansetron in 10 ml 0.9% saline and groups PI, PIP, and PP received 10 ml 0.9% saline before anesthesia induction. Group O received thiopental, isoflurane, nitrous oxide- oxygen, and fentanyl for anesthesia. Group PI received propofol, isoflurane, nitrous oxide- oxygen, and fentanyl. Group PIP received propofol, isoflurane, nitrous oxide- oxygen, and fentanyl. Thirty minutes before expected skin closure, isoflurane was discontinued and 50 to 150 micrograms.kg-1.min-1 propofol was given intravenously to maintain anesthesia. Group PP received propofol for induction and maintenance of anesthesia, nitrous oxide- oxygen, and fentanyl. Postoperative pain relief was provided with morphine administered by a patient-controlled analgesia pump. The incidence of nausea and vomiting, requests for rescue antiemetic and sedation, pain scores, and hemodynamic data were recorded for 24 h. RESULTS: Within 6 h of surgery, groups O and PP had a lower incidence of nausea compared with groups PI and PIP (P < 0.05). Fewer patients in group PP (19%) vomited during the 24-h period compared with groups O (48%), PI (64%), and PIP (52%) (P < 0.05). The incidence of antiemetic use was also less in group PP (P < 0.05). Patients in group PP had lower sedation scores at 30 min and at 1 h (P < 0.05). There were no differences among the groups in pain scores, blood pressure, heart rate, respiratory rate, and incidence of pruritus. CONCLUSIONS:
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Authors | T J Gan, B Ginsberg, A P Grant, P S Glass |
Journal | Anesthesiology
(Anesthesiology)
Vol. 85
Issue 5
Pg. 1036-42
(Nov 1996)
ISSN: 0003-3022 [Print] United States |
PMID | 8916820
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Breast
(surgery)
- Double-Blind Method
- Female
- Humans
- Metabolic Clearance Rate
- Middle Aged
- Nausea
(prevention & control)
- Ondansetron
(administration & dosage)
- Postoperative Complications
(prevention & control)
- Propofol
(administration & dosage, pharmacokinetics)
- Vomiting
(prevention & control)
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