Sialyl Lewis X analog inhibits eosinophil accumulation and late asthmatic response in a guinea-pig model of asthma.

Preferential eosinophil accumulation is characteristic of airway inflammation in asthma. Although little is known about its mechanism, the effect of a sialyl Lewis X analog on airway eosinophilia was examined in a guinea-pig model of asthma. Guinea-pigs were sensitized by repeated inhalation of ovalbumin. After a single inhalation challenge, the animals showed striking airway eosinophilia and a late asthmatic response. In contrast, when guinea-pigs were pretreated intravenously with sialyl Lewis X analog (LX 0104) 1 h before antigen challenge, both eosinophil infiltration in the tracheal wall and the late asthmatic response were significantly inhibited in a dose-dependent manner. In a further in vitro study, LX 0104 significantly suppressed the adhesion of human and guinea-pig eosinophils to human umbilical vein endothelial cells activated with interleukin-1 beta. These results suggest that LX 0104 plays a critical role in antigen-induced airway eosinophilia and the late asthmatic response.
AuthorsH Sagara, C Ra, T Okada, S Shinohara, T Fukuda, K Okumura, S Makino
JournalInternational archives of allergy and immunology (Int Arch Allergy Immunol) Vol. 111 Suppl 1 Pg. 32-6 ( 1996) ISSN: 1018-2438 [Print] SWITZERLAND
PMID8906110 (Publication Type: Journal Article)
Chemical References
  • 5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine
  • Anti-Inflammatory Agents
  • LX 0104
  • Oligosaccharides
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Asthma (drug therapy)
  • Cell Adhesion (drug effects)
  • Cells, Cultured
  • Chemotaxis, Leukocyte (drug effects)
  • Cross Reactions
  • Endothelium, Vascular (cytology)
  • Eosinophils (immunology)
  • Guinea Pigs
  • Humans
  • Male
  • Oligosaccharides (pharmacology)
  • Time Factors

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