Abstract |
Preferential eosinophil accumulation is characteristic of airway inflammation in asthma. Although little is known about its mechanism, the effect of a sialyl Lewis X analog on airway eosinophilia was examined in a guinea-pig model of asthma. Guinea-pigs were sensitized by repeated inhalation of ovalbumin. After a single inhalation challenge, the animals showed striking airway eosinophilia and a late asthmatic response. In contrast, when guinea-pigs were pretreated intravenously with sialyl Lewis X analog ( LX 0104) 1 h before antigen challenge, both eosinophil infiltration in the tracheal wall and the late asthmatic response were significantly inhibited in a dose-dependent manner. In a further in vitro study, LX 0104 significantly suppressed the adhesion of human and guinea-pig eosinophils to human umbilical vein endothelial cells activated with interleukin-1 beta. These results suggest that LX 0104 plays a critical role in antigen-induced airway eosinophilia and the late asthmatic response.
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Authors | H Sagara, C Ra, T Okada, S Shinohara, T Fukuda, K Okumura, S Makino |
Journal | International archives of allergy and immunology
(Int Arch Allergy Immunol)
Vol. 111 Suppl 1
Pg. 32-6
( 1996)
ISSN: 1018-2438 [Print] Switzerland |
PMID | 8906110
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- LX 0104
- Oligosaccharides
- Sialyl Lewis X Antigen
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Asthma
(drug therapy)
- Cell Adhesion
(drug effects)
- Cells, Cultured
- Chemotaxis, Leukocyte
(drug effects)
- Cross Reactions
- Endothelium, Vascular
(cytology)
- Eosinophils
(immunology)
- Guinea Pigs
- Humans
- Male
- Oligosaccharides
(pharmacology)
- Sialyl Lewis X Antigen
- Time Factors
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