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The effect of vitamin E on ipsilateral and contralateral testis following unilateral testicular torsion in rats.

Abstract
An experimental study was conducted to investigate the role of lipid peroxidation in ipsilateral and contralateral testicular reperfusion injury following unilateral testicular torsion (TT) and the effect of vitamin E in the management of this injury. Fifty adult male Sprague-Dawley rats were divided into five equal groups. Bilateral orchiectomy was performed immediately in group 1, and 3 h after unilateral TT in group 2. In group 3, both testes were harvested 3 h after a sham operation. In groups 4 and 5, unilateral TT, detorsion after 3 h and bilateral orchiectomy after 6 h were performed. Vitamin E was given before detorsion in group 4 and after detorsion in group 5. The levels of malondialdehyde (MDA) were measured as an index of lipid peroxidation in all testes. There were no significant differences between right and left testes within groups or between right or left testicular MDA values in different groups. The results suggest that lipid peroxidation does not play an important role in ipsilateral and contralateral testicular injury following unilateral TT and that vitamin E given before or after detorsion of testes is not useful in preventing testicular reperfusion injury.
AuthorsC Turan, N Küçükaydin, A Bekerecioğlu, A Kazez, P Doğan, M Küçükaydin
JournalResearch in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie (Res Exp Med (Berl)) Vol. 196 Issue 4 Pg. 243-6 ( 1996) ISSN: 0300-9130 [Print] Germany
PMID8903100 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Vitamin E
  • Malondialdehyde
Topics
  • Animals
  • Lipid Peroxidation (physiology)
  • Male
  • Malondialdehyde (analysis, metabolism)
  • Orchiectomy
  • Rats
  • Rats, Sprague-Dawley
  • Reperfusion Injury (metabolism, therapy)
  • Testis (drug effects, metabolism)
  • Vitamin E (pharmacology)

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