The effect of incubation of plasma with
lipoprotein lipase on
factor VII coagulant (
FVII:C) activity was examined in 40 patients, 22 male and 18 female, aged 28 to 77 years, with history of venographically proven
deep venous thrombosis (DVT). While the mean (+/-SEM)
FVII:C activity of the 40 patients was 100.9 +/- 4.1%, 19 patients had
FVII:C activity less than 100%, 11 had 100 to 120% activity and 10 patients had greater than 120%
FVII:C activity. The mean
triglyceride level of all the patients was 84.0 +/- 6.5 mg/dl. The
FVII:C activity correlated significantly with
triglyceride (r = 0.36; n = 40; p = 0.021). There was about 30% average loss of
FVII:C activity upon incubation of plasma with
lipoprotein lipase. The mean activity loss increased from 23.8% to 31.5% and 42.6% in patients whose
FVII:C activity levels were less than 100%, between 100 and 120% and more than 120% respectively, the variation in the means being statistically significant (p < 0.001). While according to current opinion,
FVII:C activity represents the total FVII mass (FVII plus FVIIa) and activity state, the present findings demonstrate a
lipid dependence of
FVII:C activity, and raises the possibility of a therapeutic option of controlling
FVII:C by controlling
triglyceride levels.